ABSTRACT
Antrodia camphorata, a well-known and highly valued edible medicinal mushroom with intriguing activities like liver protection, has been traditionally used for the treatment of alcoholic liver disease. A. camphorata shows highly medicinal and commercial values with the demand far exceeds the available supply. Thus, the petri-dish cultured A. camphorata (PDCA) is expected to develope as a substitute. In this paper, nineteen triterpenes were isolated from PDCA, and thirteen of them were the unique anthroic acids in A. camphorata, including the main content antcin K, which suggested that PDCA produced a large array of the same anthroic acids as the wild one. Furthermore, no obvious acute toxicity was found suggesting the edible safety of PDCA. In mice alcohol-induced liver injury model, triglyceride (TG), aspartate aminotransferase (AST), alanine aminotransferase (ALT), and malondialdehyde (MDA) had been reduced by the PDCA powder as well as the main content antcin K, which indicated that the PDCA could protect alcoholic liver injury in mice model and antcin K could be the effective component responsible for the hepatoprotective activities of PDCA against alcoholic liver diseases.
Subject(s)
Animals , Female , Male , Mice , Alanine Transaminase , Blood , Aldehyde Dehydrogenase , Blood , Antrodia , Chemistry , Aspartate Aminotransferases , Blood , Biological Products , Chemistry , Pharmacology , Therapeutic Uses , Chemical and Drug Induced Liver Injury , Cholestenes , Chemistry , Pharmacology , Therapeutic Uses , Cholesterol, VLDL , Blood , Disease Models, Animal , Ethanol , Toxicity , Fruiting Bodies, Fungal , Chemistry , Liver , Metabolism , Pathology , Liver Diseases, Alcoholic , Malondialdehyde , Blood , Molecular Structure , Triglycerides , Blood , Triterpenes , Chemistry , Pharmacology , Therapeutic UsesABSTRACT
Objective To investigate the therapeutic effect of buflomedil hydiochoride for on jection inpro- gressive ischemic stroke.Methods 60 patients with cerebral infarction were divided into buflomedil hydrochoride for injection treatment group and control treatment.Then the nepal function deficits of patients were evaluated before and after 15 days.Serum MMP-9 levels in vein blood samples of ischemie stroke were detected.Results The inci- dence rate of progressive ischemic stroke in treatment group of buflomedil hydrochoride for injection was lower than that of control treatment group(P